Modulation of the Inflammatory Response in Bariatric Surgery

About This Study

This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with opioids, or inhalational anesthesia with opioids. The study will measure blood levels of inflammation-related substances (such as IL-6, CRP, cortisol, ESR , WBC and lactate) at several time points before and after surgery. Heart rate variability will also be monitored as an indicator of the body's stress response. The results may help identify anesthesia strategies that reduce inflammation and improve recovery in patients undergoing bariatric surgery.

Conditions Studied

Interventions

• •Opioid-Free Anesthesia (OFA)
• •Opioid-Based Intravenous Anesthesia (OBA-IV)
• •Opioid-Based Inhalational Anesthesia (OBA-Inh)

Eligibility

Inclusion Criteria:

* Patients scheduled for bariatric surgery.
* Age 18-65 years.
* BMI ≥ 30 kg/m².
* ASA physical status II-III.

Exclusion Criteria:

* Pregnancy or breastfeeding.
* Chronic opioid use before surgery.
* Severe renal or hepatic failure.
* Uncontrolled psychiatric disorders.
* Significant intraoperative complications requiring protocol deviation.

Study Locations (1)