Comparative Study of Opioid-Free Anesthesia Versus Opioid Anesthesia in Patients Undergoing Laparoscopic Cholecystectomy

About This Study

Laparoscopic cholecystectomy is an effective surgical approach for the treatment of gallbladder disorders such as cholecystitis, gallbladder stones or gallbladder polyps. Although the surgical technique for the treatment of cholecystitis with laparoscope shows some gains compared to open surgery, postoperative complications such as abdominal incision pain, nausea and vomiting, or other complications are still challenging issues. Thus, there is a need to study and evaluate new non-opioid pain medications after laparoscopic cholecystectomy as part of an opioid reduction strategy.the aim of the study is To compare the effectiveness and safety of opioid-free anesthesia versus opioid-based anesthesia in patients undergoing laparoscopic cholecystectomy, focusing on pain management, postoperative recovery, and incidence of adverse effects.

Conditions Studied

Interventions

• •Nalbuphine
• •Dexmedetomidine

Eligibility

Inclusion Criteria:

* o Adults aged 18-65 years.

  * Scheduled for elective laparoscopic cholecystectomy.
  * ASA Physical Status I-III.
  * Provided informed consent.

Exclusion Criteria:

* patients with a history of alcohol or drug abuse.

  * Chronic opioid use or dependence.
  * basal heart rate (HR) ≤ 50 beats/min.
  * Allergies to study medications.
  * Severe renal or hepatic impairment.
  * Pregnancy or lactation.