Non-steroidal Anti-inflammatory Drugs in Pleurodesis

About This Study

Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use. However, there is a controversy in its use in pleurodesis surgery as it could block the process of pleurodesis in surgical pneumothorax. In addition, NSAIDs could increase the risk of pneumothorax recurrence. The investigators hypothesized that NSAIDs are safe during pleurodesis with a better pain management without increasing the risk of pneumothorax reccurence.

Conditions Studied

Interventions

• •pleurodesis procedures
• •KETOPROFEN(RP19583)
• •Placebo

Eligibility

Inclusion Criteria:

* Age≥18-year-old
* pneumothorax with an indication of pleurodesis
* with or without minimal lung resection
* via thoracotomy or thoracoscopy

Exclusion Criteria:

* Minor patient
* Pregnant, parturient or breast-feeding patient
* Severe polytrauma (associated with the presence of a Vittel criterion)
* Purulent pleurisy
* Hemopneumothorax
* Lactose hyper sensibility
* Contraindications to NSAID
* Contraindications to tramadol
* Contraindications to paracetamol
* Curative anticoagulation
* Patients under guardians or deprived of their liberty
* Patient refusal

Study Locations (1)