Not Yet RecruitingPhase 4ketamine
Effects of Minimal-Flow Sevoflurane and Multimodal Analgesia in Head and Neck Cancer Surgery
Sponsored by National Taiwan University Hospital
NCT ID
NCT06521697
Target Enrollment
60 participants
Start Date
2024-08
Est. Completion
2025-12
About This Study
This study evaluates the anesthetic-sparing and renal protection effects of minimal-flow sevoflurane anesthesia combined with multimodal analgesia using dexmedetomidine, ketamine, and lidocaine in head and neck cancer patients undergoing free flap microvascular surgery. The 2x2 factorial randomized controlled trial aims to compare sevoflurane usage and renal function changes with different fresh gas flow rates and multimodal analgesia.
Conditions Studied
Interventions
- •Multimodal analgesia using dexmedetomidine-ketamine-lidocaine mixture
- •Minimal flow sevoflurane
Eligibility
Age:18 Years - 99 Years
Healthy Volunteers:No
View full eligibility criteria
Inclusion Criteria: * Age 18-99 years * Scheduled for head and neck cancer tumor resection and free flap reconstruction surgery Exclusion Criteria: * Preoperative tracheostomy * History of previous head and neck cancer tumor resection * Anemia (hematocrit \<30% or recent transfusion) * Hypertension on ACEI/ARB medications * Significant medical conditions (e.g., NYHA class 3 or 4 heart failure, eGFR \<60 ml/min/1.73 m², Child B or C liver failure, severe respiratory disorders, pre-existing cognitive impairment) * ASA physical status 4 or 5 * Allergies to sevoflurane, dexmedetomidine, ketamine, or lidocaine