RecruitingPhase 2psilocybin

Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder

NCT ID

NCT05995769

Target Enrollment

128 participants

Start Date

2024-03-20

Est. Completion

2027-10-01

About This Study

The aim of this study is to determine if a single dose of psilocybin administered with motivational enhancement therapy (MET) can reduce heavy drinking in patients with an alcohol use disorder (AUD).

Conditions Studied

Alcohol Use DisorderAlcoholism

Interventions

•Psilocybin

Eligibility

Age:22 Years - 65 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Meets DSM-5 AUD criteria of at least moderate severity
* Meets heavy drinking requirements (heavy drinking days, number of drinks) in past 30 days
* Desire to decrease alcohol consumption
* Limited lifetime hallucinogen use

Exclusion Criteria:

* Severe or moderate substance use disorder other than alcohol or nicotine in past 6 months
* Diagnosis of schizophrenia, bipolar disorders or first-degree relative with diagnosis
* Active suicidal ideation or serious attempt within past 3 years
* Currently pregnant, nursing, or trying to become pregnant
* Any notable abnormality on ECG, physical exam, or routine medical blood laboratory test

Study Locations (1)

University of Calgary