RecruitingPhase 3Other

Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs

NCT ID

NCT04928300

Target Enrollment

60 participants

Start Date

2021-06-12

Est. Completion

2027-07-25

About This Study

In our study, we assess the diaphragmatic function, pain quality and anti-inflammatory properties between low dose infusion of dexmedetomidine normal saline in patients with multiple fracture ribs on conservative treatment.

Conditions Studied

Rib Fractures

Interventions

•Dexmedetomidine
•0.9% saline

Eligibility

Age:18 Years - 65 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Adults (age 18-65 years) of American Society of Anaesthesiologists (ASA) physical status I-II
* Traumatic multiple fracture ribs 3 ribs or more, who will be subjected to thorough assessments including chest 3D-CT
* Undergoing conservative treatment (chest strappings)
* Intractable pain with visual analogue scale (VAS) over 6 after traditional therapies
* Glasgow Coma Scale (GCS) ≥ 13.

Exclusion Criteria:

* Multiple traumas to body parts other than chest with an abbreviated injury scale over 3
* Serious head trauma with a Glasgow coma scale lower than 13
* Mechanically ventilated patients
* Massive hemothorax
* Injury to the trachea or bronchus with requirement for immediate surgery
* Dementia
* Use of corticosteroids during ICU stay
* Sepsis
* Continued use of neuromuscular blocking agents and aminoglycosides antibiotic use as they are known risk factors for ICU-acquired weakness and any known hypersensitivity
* Contraindication to the study drugs.

Study Locations (1)

Assiut university hospital